Dimethyl Sulfoxide
Apexbio Technology LLC Levetiracetam 102767-28-2 10mM (in 1mL DMSO)
Levetiracetam (CAS 102767-28-2) is an antiepileptic small-molecule agent recognized for its distinct mode of action compared to traditional anticonvulsants It binds selectively to synaptic vesicle glycoprotein 2A (SV2A) a protein involved in the regulation of intracellular calcium dynamics and neurotransmitter release Mechanistically levetiracetam negatively modulates gamma-aminobutyric acid (GABA)- and glycine-gated neuronal currents Importantly levetiracetam does not induce hepatic cytochrome P450 enzymes exhibits negligible plasma protein binding and is predominantly excreted unchanged renally with partial hydrolytic metabolism clinically levetiracetam is utilized widely in research addressing partial and generalized epileptic seizures
Apexbio Technology LLC ZM 447439 331771-20-1 10mM (in 1mL DMSO)
ZM 447439 (CAS 331771-20-1) is a selective inhibitor of Aurora kinases a subgroup within the serine/threonine kinase family involved in chromosome segregation during cell division It inhibits recombinant Aurora A and Aurora B kinases with IC50 values of approximately 110 nM and 130 nM respectively consequently reducing phosphorylation of histone H3 at serine 10 ZM 447439 demonstrates limited inhibitory activity towards other kinases with IC50 values above 10 M for CDK1/2/4 IKK1/2 PLK1 CHK1 cFLT2 KDR2 FAK and Zap-70 In biological research ZM 447439 is commonly employed to study mitotic regulation chromosomal alignment and apoptosis signaling pathways
Apexbio Technology LLC Prucalopride 179474-81-8 10mM (in 1mL DMSO)
Prucalopride (CAS 179474-81-8) is a selective serotonin 5-HT4 receptor agonist with high affinity for both 5-HT4A and 5-HT4B receptor subtypes demonstrating Ki values of 2 5 nM and 8 nM respectively It displays substantial selectivity exceeding 290-fold against other serotonin receptor classes By activating 5-HT4 receptors prucalopride promotes gastrointestinal motility making it a valuable tool compound for investigating serotonergic mechanisms underlying gastrointestinal disorders and motility regulation Currently prucalopride is evaluated in Phase 3 clinical trials
Apexbio Technology LLC Busulfan 55-98-1 10mM (in 1mL DMSO)
Busulfan is a DNA alkylating agent widely used in biomedical research as an anticancer compound It functions by forming cross-links on guanine bases within DNA leading to DNA damage and subsequent inhibition of cell growth and proliferation In vitro studies reveal that exposure to busulfan (IC50 range approximately 7 5 120 M) promotes cellular senescence in normal human fibroblast cell lines mediated through increased reactive oxygen species (ROS) and sustained activation of MAPK signaling pathways Additionally busulfan is utilized in fertility and reproductive biology research due to its ability to induce apoptosis in male germ cells reducing germ cell populations in experimental mouse models
Apexbio Technology LLC Epoxomicin 134381-21-8 10mM (in 1mL DMSO)
Epoxomicin (CAS 134381-21-8) is a naturally occurring proteasome inhibitor initially isolated from actinomycete cultures It acts primarily by forming covalent bonds through its -epoxyketone moiety with catalytic residues of the proteasome resulting in potent inhibition of the chymotrypsin-like (CTRL) activity of the 20S proteasome subunit Epoxomicin also inhibits proteasomal trypsin-like and peptidyl-glutamyl peptide hydrolysis activities albeit at significantly lower rates It exhibits anti-inflammatory and antitumor activities and is employed experimentally to study ubiquitin-proteasome-mediated cellular pathways bone formation regulation and Parkinson s disease model generation
Medchemexpress LLC IRG1 IN 1 10 MM 1 ML IN DMSO
IRG1-IN-1 10 mM 1 mL in DMSO ready for reconstitution
Apexbio Technology LLC PTC-209 315704-66-6 10mM (in 1mL DMSO)
PTC-209 (CAS 315704-66-6) is a small-molecule inhibitor targeting BMI-1 identified through Gene Expression Modulation by Small molecules (GEMS) technology It acts by suppressing BMI-1 expression at the transcriptional level displaying an IC50 of approximately 0 5 M In HCT116 cells PTC-209 reduces both UTR-mediated and endogenous BMI-1 expression It selectively restricts cell proliferation in certain tumor and stem cell types including U937 HT1080 and human hematopoietic stem cells without affecting viability in cell lines such as HEK293 and HT1080 Thus PTC-209 is primarily utilized in studies exploring cancer stem cell growth and oncogenesis involving BMI-1 and the PRC1 complex
Apexbio Technology LLC HTH-01-015(Synonyms: HTH01015, WZ4003, NUAK1 inhibitor WZ4003, NUAK1-IN-1, NUAK1 inhibitor, WZ-4003), 10mM (in 1mL DMSO), CAS: 1613724-42-7.
HTH-01-015 (CAS 1613724-42-7) is a highly selective inhibitor targeting the NUAK1 kinase exhibiting potent inhibitory activity with an IC50 of approximately 100 nM It specifically blocks NUAK1-mediated phosphorylation of MYPT1 at Ser445 with negligible off-target effects among a comprehensive panel of 139 other kinases Cellular studies demonstrate that treatment with HTH-01-015 reduces migration of mouse embryonic fibroblasts (MEFs) suppresses proliferation in U2OS and MEF cell lines at concentrations around 10 M and significantly inhibits invasion of U2OS cells within 3D Matrigel transwell assays This compound serves as a useful research tool for investigating NUAK1-related signaling pathways in cancer biology and cellular dynamics
Apexbio Technology LLC Lovastatin 75330-75-5 10mM (in 1mL DMSO)
Lovastatin (CAS 75330-75-5) is an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) a rate-controlling enzyme in cholesterol biosynthesis that mediates conversion of HMG-CoA to mevalonate In vitro assays show that lovastatin inhibits HMG-CoA reductase activity with IC50 values of 2 3 nmol/L in rat hepatocytes and 5 nmol/L in human hepatoma HepG2 cells By decreasing mevalonate and subsequent isoprenoid intermediates lovastatin reduces cellular proliferation and DNA synthesis It also enhances macrophage-mediated clearance of apoptotic cells at concentrations around 5 M Lovastatin serves as a useful tool in studies investigating lipid metabolism cellular proliferation pathways and related inflammatory processes
Apexbio Technology LLC Nicardipine HCl 54527-84-3 10mM (in 1mL DMSO)
Nicardipine HCl (CAS 54527-84-3) is a dihydropyridine-derived small molecule that functions primarily as a calcium-channel blocker through inhibition of voltage-dependent L-type calcium channels This mechanism prevents calcium ion influx causing vasodilation and decreased vascular resistance Widely applied in vascular biology and pharmacological research nicardipine hydrochloride serves as a useful tool to explore calcium-dependent processes cardiovascular pathophysiology and therapeutic strategies targeting calcium-mediated vascular conditions
Apexbio Technology LLC Protionamide 14222-60-7 10mM (in 1mL DMSO)
Protionamide is a thiophene-derived antibacterial compound that inhibits the synthesis of mycolic acids a major component of the mycobacterial cell wall Through disruption of mycolic acid biosynthesis it interferes with cell wall integrity exhibiting antibacterial activity against pathogenic mycobacteria Protionamide is commonly employed in research involving Mycobacterium tuberculosis and Mycobacterium leprae primarily for investigating molecular mechanisms underlying drug resistance and cell wall biosynthesis pathways In laboratory experiments this compound is frequently utilized in vitro for cultivation assays antimicrobial screening and studies on synergistic effects when combined with other antimycobacterial agents It demonstrates reported IC50 values in the micromolar range dependent on experimental conditions and mycobacterial strains used