Dimethyl Sulfoxide
Apexbio Technology LLC Zafirlukast 107753-78-6 10mM (in 1mL DMSO)
Zafirlukast (CAS 107753-78-6) is an antagonist targeting cysteinyl leukotriene receptors (CysLTR) which mediate inflammatory signaling pathways By competitively inhibiting leukotriene receptor binding it disrupts the leukotriene-driven inflammatory response Zafirlukast demonstrates antagonist potency against leukotriene receptors with an IC50 value of approximately 0 6 M and exhibits moderate inhibitory activity on CYP2C9 enzyme (IC50 of about 7 0 M) In biomedical research Zafirlukast serves as a pharmacological tool for studying leukotriene-mediated inflammation and receptor signaling processes
Apexbio Technology LLC GW788388 452342-67-5 10mM (in 1mL DMSO)
GW788388 (CAS 452342-67-5) is a selective inhibitor targeting activin receptor-like kinase 5 (ALK5) the type I receptor for transforming growth factor-beta (TGF- ) It inhibits the kinase activity of ALK5 suppressing TGF- -mediated signaling cascades GW788388 demonstrates potent inhibition of ALK5 autophosphorylation with an IC50 of 18 nM leading to decreased Smad2 phosphorylation It also inhibits TGF- -induced epithelial-mesenchymal transition (EMT) cellular proliferation fibrosis and angiogenesis in various cell models such as NMuMG MDA-MB-231 RCC and U2OS In animal studies GW788388 ameliorates renal fibrosis in diabetic db/db mouse models highlighting its utility in investigating TGF- -driven pathophysiological processes
Apexbio Technology LLC N6-methyladenosine (m6A) 1867-73-8 10mM (in 1mL DMSO)
N6-methyladenosine (m6A) is a purine derivative functioning primarily as an adenosine receptor agonist and modulates adenylate cyclase activity with reported ED50 approximately 17 25 M It is a common internal modification in eukaryotic messenger RNAs predominantly occurring within consensus motif RRACH (R G or A H A C or U) and affecting RNA stability processing and translation Experimental studies indicate m6A application in cellular models such as murine erythroleukemia (MEL) cells reduces -globin mRNA accumulation thereby suppressing erythroid differentiation initiation Due to its epigenetic regulatory role m6A serves as a tool for studying RNA methylation-dependent gene expression and cellular differentiation
Apexbio Technology LLC MK-8745 885325-71-3 10mM (in 1mL DMSO)
MK-8745 (CAS 885325-71-3) is a small-molecule inhibitor targeting Aurora A kinase a serine/threonine kinase regulating chromosomal segregation during mitosis Aberrant Aurora A activity correlates with cancer progression In preclinical studies MK-8745 suppresses Aurora A kinase eliciting p53-dependent apoptosis and G2/M cell cycle arrest MK-8745 demonstrates antitumor activity in vitro across various cancer cell lines including p53-deficient and checkpoint-defective HCT116 variants and inhibits tumor growth in xenografted tumor models signifying its potential utility in cancer research targeting Aurora kinase pathways
Apexbio Technology LLC Danusertib (PHA-739358) 827318-97-8 10mM (in 1mL DMSO)
Danusertib (PHA-739358 CAS 827318-97-8) is a pyrrolopyrazole-based aminopyrazole derivative that functions as a pan-inhibitor of aurora kinases prominently targeting aurora B kinase (ABK) It also exhibits inhibitory activity against several other tyrosine kinases including the T315I mutant form RET TRK-A and fibroblast growth factor receptor-1 (FGFR-1) Due to its broad kinase inhibition profile danusertib has demonstrated significant antitumor activity in various xenograft spontaneous and genetically engineered animal models and is thus useful in oncology research involving leukemia and solid tumors
Apexbio Technology LLC EPZ-6438 1403254-99-8 10mM (in 1mL DMSO)
EPZ-6438 is a selective inhibitor targeting EZH2 the catalytic subunit of polycomb repressive complex 2 (PRC2) By competitively binding to EZH2 s S-adenosylmethionine (SAM) pocket EPZ-6438 suppresses EZH2-driven trimethylation of histone H3 lysine 27 (H3K27me3) a key epigenetic modification implicated in transcriptional regulation and oncogenesis This selective inhibition of EZH2 exhibits reduced affinity for EZH1 In biological studies EPZ-6438 has demonstrated anti-tumor activity in preclinical malignant rhabdoid tumor models making it useful for examining EZH2-dependent cancer pathways and epigenetic research
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide United States Pharmacopeia (USP) Reference Standard | 67-68-5 | MFCD00002089 | 3G
Dimethyl sulfoxide United States Pharmacopeia (USP) Reference Standard | Mol Wt: 78.13 | 67-68-5 | MFCD00002089 | 3G
Apexbio Technology LLC Laquinimod (ABR-215062) 248281-84-7 10mM (in 1mL DMSO)
Laquinimod (ABR-215062 CAS 248281-84-7) is an orally bioavailable immunomodulatory small molecule Research studies demonstrate that in experimental autoimmune encephalomyelitis (EAE) a widely utilized rodent model for studying human multiple sclerosis (MS) laquinimod treatment suppresses disease progression in a dose-dependent manner Mechanistically the compound reduces inflammatory infiltration of CD4 T lymphocytes and macrophages into the central nervous system thereby modulating the Th1/Th2 immune response and inducing regulatory cytokines such as TGF- Clinical investigations into relapsing MS indicate that laquinimod administration correlates with reduced disease activity clinical relapse rate MRI-measured lesions and brain volume loss
Apexbio Technology LLC Micafungin sodium 208538-73-2 10mM (in 1mL DMSO)
Micafungin sodium is an antifungal agent that acts by inhibiting the synthesis of 1 3- -D-glucan an essential polymer for fungal cell wall integrity particularly in Candida albicans In addition to antifungal activities micafungin has been studied for its capacity to suppress biofilm formation by Pseudomonas aeruginosa via downregulation of genes encoding structural biofilm elements such as algC and pelC and the 1 3- -D-glucan-encoding gene ndvB Micafungin has demonstrated synergy with other antifungal compounds in animal models in murine models of systemic Aspergillus fumigatus infection micafungin administration resulted in increased survival rates Micafungin is utilized in biomedical research to investigate antifungal mechanisms combination therapies and inhibition of pathogen biofilms Reported inhibitory activity (IC50) for fungal glucan synthase typically falls within the nanomolar range
Apexbio Technology LLC Bedaquiline 843663-66-1 10mM (in 1mL DMSO)
Bedaquiline a diarylquinoline antibiotic targets Mycobacterium tuberculosis via dual inhibition of subunits c and within the bacterial F1FO-ATP synthase complex disrupting ATP production It is applied primarily in research addressing multi-drug resistant (MDR) tuberculosis Recent studies have expanded its use into oncology where bedaquiline inhibits mitochondrial respiratory function and reduces glycolytic activity in cancer stem-cell-like populations In vitro experiments employing breast cancer MCF7 cells revealed bedaquiline increased ROS levels and reduced mitochondrial membrane potential Reported IC50 values for growth inhibition range approximately 1-10 M depending on cell lines and experimental conditions
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide | 67-68-5 | MFCD00002089 | 500 mL
Dimethyl sulfoxide | Purity: ≥99.7% | Mol Wt: 78.13 | 67-68-5 | MFCD00002089 | 500 mL
Apexbio Technology LLC MK 0893 870823-12-4 10mM (in 1mL DMSO)
MK 0893 is a small molecule antagonist targeting both the glucagon receptor (GCGR) and insulin-like growth factor-1 receptor (IGF-1R) It competitively and reversibly inhibits glucagon binding to GCGR subsequently reducing receptor-mediated cAMP production In cell-based assays utilizing CHO cells expressing human GCGR MK 0893 showed nanomolar-level inhibitory potency with a receptor binding IC50 around 6 6 nM and a cellular cAMP inhibition IC50 near 15 7 nM Additionally MK 0893 exhibits potent inhibitory activity on IGF-1R demonstrated in IGF-1-driven mouse xenograft tumor models Therefore MK 0893 serves as a relevant pharmacological tool in research related to type 2 diabetes and IGF-1R-mediated oncogenic signaling pathways